2015-02-01 · In conclusion, Lgr5, a putative cancer stem cell marker, is frequently over-expressed in cervical cancer tissues. The Lgr5 may play an important role in cervical tumorigenesis and tumor development, and would be a powerful biomarker to predict the prognosis of cervical cancer patients, especially of advanced stage patients.
2014-06-01
Figure from citation: Immunohistochemistry analysis of stem cell marker LGR5 by Clone DB105 recognizes the CD44 antigen. CD44 is a marker for many types of cancer stem cells (CSCs Labeling Check Reagents. The Labeling 29 Dec 2016 If this is the case, a given CSC marker should be intimately associated with both stemness and EMT regulators. LGR5 has been reported to be a cells. In recent years, Lgr5, leucine-rich repeat-containing.
As Wnt signaling is also involved in brain development, the function of LGR5 in the maintenance of brain CSCs is to be assessed. 2012-11-15 · Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival Abstract. Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) has recently been identified as an Background. Tumor progression may be related to the alteration of genes that regulate Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis 2010-01-08 · We recently identified the orphan G protein-coupled receptor Lgr5 (also known as Gpr49) as a marker of active stem cells in the small intestine, colon, and hair follicles (Barker et al., 2007, Jaks et al., 2008). We show that Col22a1, a marker of early articular chondrocytes, is co-expressed with Lgr5 + cells prior to cavitation as an important lineage marker specifying the progression toward articular chondrocytes. Lgr5 + cells contribute to the repair of a joint defect with the re-establishment of a Col22a1-expressing superficial layer. 2012-10-05 · The first marker to be discussed here is Lgr5, a specific CBC cell marker.
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a Wnt-associated stem cell marker, has been extensively studied in intestinal stem cells, but little is known about its expression in human liver. We hypothesized that LGR5+ HPCs are induced in the regenerative response to pediatric liver injury.
Epub 2014 Sep 2. LGR5, a relevant marker of cancer stem cells, indicates a poor prognosis in colorectal cancer patients: a meta-analysis. Lgr5, leucine-rich repeat-containing G-protein coupled receptor 5, is a bona fide biomarker for stem cells in multiple tissues. Lgr5 is also expressed in the brain, but the identities and properties of these Lgr5 + cells are still elusive.
intense Lgr5 immunostaining in BE-associated dysplastic lesions, esophageal adenocarcinoma (EAC), and gastric carcinoma (data not shown). Given its role as an intestinal stem cell marker, Lgr5 gene expression in cancer has led to speculation regarding its potential as a CSC marker[13,14,15]. To explore
Interestingly the DCLK1 expression level was significantly higher in patients undergoing preoperative CRT (p = 0.041); however, no association to neoadjuvant CRT was observed for Lgr5. 2014-05-21 2018-09-12 2019-10-08 2017-09-25 2012-04-05 Background Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) has recently been identified as an intestinal stem cell marker. In order to determine whether Lgr5 is a potential 2021-03-06 2020-06-10 2010-02-01 2019-09-24 Analyses of Wnt/β-catenin signaling in human colorectal cancer , Lgr5-EGFP+ stem cell transformation in a mice model and the tumor initiating potential of single-cell-cloned cancer stem cells on xenotransplants suggest that stem cell like cells are involved in colorectal carcinogenesis and that these cells can be identified, among others, by the marker Lgr5. 2020-09-07 2012-07-11 Lgr5 is a Wnt target gene; the G protein‐coupled receptor Lgr5 has been shown to mark stem cells in multiple regenerative tissues [6-9]. Lgr5 and its homologs interact with R‐spondins to augment Wnt signaling [23-25]. Conventional deletion of the Lgr5 gene results in mice with neonatal lethality associated with craniofacial defects . LGR5, which is associated with apoptosis, cell cycle, and signal transduction, was relatively enriched in cancer cells.
Of note, all these markers were validated in the initial studies by genetic lineage tracing ( Sangiorgi and Capecchi, 2008 ; Montgomery et al , 2011 ; Takeda et al , 2011 ; Powell et al , 2012 ). 2019-10-08
Multipotent stem cells and their lineage-restricted progeny drive nephron formation within the developing kidney.
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Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5, also known as Gpr49) was selected from a panel of intestinal Wnt target genes for its restricted crypt expression.
As Wnt signaling is also involved in brain development, the function of LGR5 in the maintenance of brain CSCs is to be assessed. Our study showed that the LGR5 transcript level was increased in CSCs. 2007-10-14
2012-10-05
Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5), a recently discovered intestinal stem cell marker, is expressed in premalignant lesions including Barrett's esophagus (BE) and cancers including colon cancer, ovarian cancer, and hepatocellular carcinoma. 2017-01-09
2012-11-15
2017-04-24
Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5, also known as Gpr49) was selected from a panel of intestinal Wnt target genes for its restricted crypt expression.
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history of three related shrub species using genome-wide molecular markers. LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells
Clonal Lgr5‐derived colon organoids can be grafted into recipient mice to yield functionally normal epithelium that persists for >6 months (Yui et al, 2012). 2021-02-10 · Among HFSCs, several stem cells, such as CK15-, Lgr5-, Lgr6-, and Lrig1-expressing cells, show plasticity and have the ability to regenerate entire HFs following full-thickness wounds as well as Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis 2012-10-05 · The first marker to be discussed here is Lgr5, a specific CBC cell marker. The Lgr5 gene is controlled by Wnt signals (van de Wetering et al., 2002; van der Flier et al., 2007) and itself encodes a facultative component of the Wnt receptor complex (Carmon et al., 2012; de Lau et al., 2011).
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Semantic Scholar - 1034 x 584 · png stem cancer lgr spondin cells wnt cell antibody frizzled colorectal lgr5 catenin membrane ligands signalling marker 141 Andra arbeten visar dock att Lgr5 + -Axin2 + pericentral hepatocyter sällan strictly be categorized as M1 or M2 as they express markers of both subtypes. Flera CSC-markörer har identifierats, inklusive CD44, CD133, Lgr5 och at a time when there are no other available serum or fecal markers that can help LGR5 - annan intressant E-RG-specifik gen (kompletterande fig.